Furan thiamine hydrochloride, calculated on dry goods, including hydrochloric acid fursultiamine (C17H26N4O3S2 • HCl) should be from 97.0% to 103.0%. Characters as white or almost white crystalline powder; odorless or slight smell similar to garlic. This product is soluble in water, slightly soluble in ethanol, benzene or ether almost insoluble. To about 50mg, accurately weighed, according to the oxygen flask combustion method (Chinese Pharmacopoeia 2000 edition of Appendix Ⅶ C) organic damage to the hydrogen peroxide solution (3 → 100) 10ml as absorbent, shaking so completely absorbed after heated to boiling, remove excess hydride hydrogen, let cool, precision by adding barium chloride - magnesium chloride mixed solution (6g take barium chloride and magnesium chloride 5g, add water to dissolve 500ml) 10ml, add a few drops of methyl red indicator, dropping 1mol / L sodium hydroxide solution until the solution was yellow, add ammonia - ammonium chloride buffer (pH10.0) 15ml with a small amount of chrome black T indicator, (0.05mol / L) titration with ethylene diamine tetra-acetic acid disodium titrant to blue, and titration with blank test correction. Each 1ml disodium ethylene diamine tetra-acetic acid titration solution (0.05mol / L) is equivalent to 10.88 in C17H26N4O3S2 • HCl. |