Degenerative joint failure can improve symptoms caused by inflammation, and help patients reduce the traditional medicine of non-steroidal anti-inflammatory drugs (NSAIDS) use; studies have shown that avocado / soybean extracts as a long-term sexual health ingredients, can long continue to improve joint failure. Avocado / soybean unsaponifiables (ASU) in the proportion of one-third to two-thirds, respectively, by avocado and soybean unsaponifiable fractions. Pre-clinical studies at Arizona State University has shown some anti-osteoarthritis performance. In vitro, ASU interleukin -1 (IL-1) inhibitory effect, and in articular cartilage cells in culture (stimulate collagen synthesis In another in vitro model, ASU prevent the deleterious effects of IL-1 on synovial cells section and cancel their rabbit articular chondrocytes. ASU can also inhibit the IL-1β stimulation of stromelysin and IL-6, collagenase synthesis of IL-8, and prostaglandin E 2 (PGE 2) production and decreased IL-1β stimulation. In addition, the recent adoption of reverse transcription - polymerase chain reaction showed, ASU could have a role in anabolic stimulation (expression of transforming growth factor β1 and plasminogen activator inhibitor-1) by articular chondrocytes. In vivo, ASU significantly prevent bruised cartilage lesions occur in OA postcontusive rabbit model.