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Bitter peptides extracted key patents for hypoglycemic do with. Has been the United States - Japan, Taiwan, and other countries Aumont Union patent regulation of blood sugar. For sugar and fat. Anti-inflammatory Prevention of fatty liver and other effects. Bitter peptides for action - Diabetes mellitus has been considered a major health problem in the world today.Is a metabolism of carbohydrates, fat and protein metabolism disorder characterized by elevation of fasting and postprandial glucose levels (Yuan et al., 2008). Is due to two insulin deficiency and / or insulin dysfunction (Modak et al., 2007). The risk factors have a family history of diabetes, age, obesity, sedentary lifestyle, abnormal cholesterol and triglyceride levels in the blood, high blood pressure and diet. Dietary factors include not only the high-sugar, high-fat and high-calorie diet, but also has a high glycemic index (GI) diet. The concept of the gastrointestinal tract is introduced as a means to quantify the blood glucose response compared to the intake of carbohydrates in the food, the response using the standard reference food (Martin et al., 2008). The carbohydrate intake growing amount of research its relationship with diabetes concerns the impact of blood glucose concentration researchers, coronary heart disease, obesity, cataracts, and certain types of cancer (Schakel et al., 2008). Although different types of synthetic oral hypoglycemic agents And insulin for the treatment of diabetes, insulin can not use oral and synthetic drugs can have serious side effects and toxicity (Yuan et al., 2008). In the past decade, therefore, research has been focused on the scientific evaluation of traditional medicines of plant origin (Grover and Yadav, 2004). Bitter peptides (bitter gourd) is one such plant has been Often used as a drug (Grover and Yadav, 2004). Seeds of bitter gourd is usually used as a herb and / or treatment of diabetes vegetables in Southeast Asian countries (Senanayake et al., 2004). Its hypoglycemic activity has been reported Bitter peptides studied, seeds and leaves the body (Xiang et al., 2007). Khanna et al. (1981), a protein isolated from the active (polypeptide - p) seeds acid ethanol extraction, which fell bloodglucose in STZ-induced diabetic rats and increased glycolytic enzyme activity. Bitter peptides -P also has been shown to have hypoglycemic effects in juvenile and maturity-onset diabetes (Khanna et al., 1981). In vitro studies also show that bitter melon extract peptides repair of pancreatic β cells (Gordon et al., 2007). In addition to its hypoglycemic effect, bitter melon also has cholesterol-lowering effect. Serum and liver lipids, and lipid-lowering effect. Serum and liver lipids, particularly triglycerides in rats fed diets containing significant concentrations of 1% compared to bitter gourd powder reduce, bitter gourd (Senanayake et al, 2004). Found that there is an increasing interest in naturally occurring, based on the compound of the functional food ingredient of plants, This may prevent and / or improve diabetes (Schakel et al., 2008). One such food ingredient is said to have this potential is a polypeptide -k. -k Peptide is a functional food ingredient that is extracted from bitter melon seeds. It has a high homology with human insulin and helps in rejuvenating the pancreas and insulin to activate inactive. It contains 18 in a single molecule, its application as a standard amino acid food ingredient in reducing blood glucose levels and may contribute to the prevention of diabetes (Khanna, 2004). Therefore, the purpose of the present study was to determine the effect of peptides -k supplement soft roll and control blood sugar levels in healthy individuals soft roll. Release requires less time, 110 minutes decreased to baseline glucose levels compared to control soft roll, which requires 190 minutes. Paired samples tests showed that in 90,150 and 210 minutes, PPK- supplemented soft roll, when compared to a significant reduction to control softness (P <0.05) in Portugal Glucose level volume. Polypeptide further soft roll with blood glucose levels dropped to -0.9 mmol / l after 210 minutes, while the soft roll control, glucose levels dropped slightly to only -0.2 mmol / liter. Have a different blood 0.7 mmol / elevating blood glucose levels and both tests bread. This clearly shows 3 mg polypeptide -k soft roll caused a greater decrease in blood glucose level. The difference reflects the PPK, is currently in testing and control software for volume, and only after 150 minutes, 100 percent experienced a decline in blood sugar panel. This is because the response of the pancreas to release insulin only when blood glucose exceeded, which accounts for lowering blood glucose longer response time (Khanna et al., 1981). The results from the present study indicate that complement the soft bun accelerated glucose metabolism results in a rapid lowering of blood glucose levels compared to Ppk, soft roll control in healthy adults





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